EIF2AK2

Across TCGA cell cohorts, EIF2AK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,424 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible EIF2AK2-associated GO terms across cancer lineages are Regulation of stress-activated protein kinase signaling cascade, Regulation of hematopoietic stem cell differentiation, and Regulation of viral process. Each is linked with EIF2AK2 in more than 16 cancer types. Because this analysis shows association rather than direction, both EIF2AK2-to-partner and partner-to-EIF2AK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of stress-activated protein kinase signaling cascade grouped by EIF2AK2-low versus EIF2AK2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2AK2→partner) and Y-score (partner→EIF2AK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of stress-activated protein kinase signaling cascade →	+0.097	+0.833	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of hematopoietic stem cell differentiation →	+0.131	+1.741	<.001	<.001	3	16
KIDNEY	Regulation of viral process →	+0.123	+1.182	.001	.001	3	16
BREAST	Regulation of hematopoietic stem cell proliferation →	+0.212	+0.977	<.001	<.001	3	15
CNS	Regulation of hippo signaling →	+0.079	+0.876	<.001	<.001	3	15
BREAST	Negative regulation of post-translational protein modification →	+0.095	+1.095	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,424 associations by consensus.

Regulation of stress-activated protein kinase signaling cascade by EIF2AK2 expression — OVARY

Explore this box plot interactively →