EIF2A

Across TCGA pan-cancer cohorts, EIF2A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated EIF2A data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher EIF2A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF2A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where EIF2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.143	0.698	<.001	60	view →
LUAD	OS	Median	II,III,IV	0.158	0.750	<.001	18	view →
UCEC	DFS	Median	All	1.000	0.630	.024	14	view →
ESCA	DFS	Median	II,III,IV	0.148	0.525	.007	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

EIF2A–HNSC (DFS)

Open the HNSC breakdown →