EIF2A

Across TCGA patient cohorts, EIF2A mutation is significantly associated with the RNA expression of many other genes, with 1,358 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2A-associated genes across cancer lineages are RNU1-17P, PSAT1P4, and RNU1-78P. Each is linked with EIF2A in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2A-to-partner and partner-to-EIF2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-17P grouped by EIF2A-low versus EIF2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2A→partner) and Y-score (partner→EIF2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-17P →	+0.199	+2.613	<.001	<.001	3	2
UCEC	PSAT1P4 →	+0.162	+1.978	<.001	.001	3	2
BLCA	RNU1-78P →	+0.292	+6.018	<.001	.002	3	2
HNSC	SNORD116-7 →	+0.469	+6.008	<.001	.002	3	2
SCLC	G6PC2 →	+0.072	+5.189	<.001	.006	3	1
BLCA	ARHGAP42P4 →	+0.025	+5.788	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,358 associations by consensus.

RNU1-17P by EIF2A expression — UCEC

Explore this box plot interactively →