EIF2A

Across TCGA patient cohorts, EIF2A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF2A-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and Notch1. Each is linked with EIF2A in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2A-to-partner and partner-to-EIF2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by EIF2A-low versus EIF2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2A→partner) and Y-score (partner→EIF2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.159	-1.986	.016	.010	3	1
UCEC	Ku80 →	+0.199	+2.183	.032	.033	3	1
UCEC	Notch1 →	+0.179	+3.335	.001	.005	3	1
UCEC	Rab11 →	-0.126	-2.999	.027	.035	3	1
UCEC	Rad50 →	-0.200	-1.584	.035	.036	3	1
UCEC	Annexin-1 →	+0.486	+2.321	.018	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK_pT183_Y185 by EIF2A expression — UCEC

Explore this box plot interactively →