EIF2A

Across TCGA cell cohorts, EIF2A RNA expression is significantly associated with the go_rna of many other GO terms, with 2,616 significant associations in total. CNS shows the largest number of these associations.

The most reproducible EIF2A-associated GO terms across cancer lineages are Response to arsenite ion, Cellular response to arsenite ion, and Ribosomal large subunit export from nucleus. Each is linked with EIF2A in more than 15 cancer types. Because this analysis shows association rather than direction, both EIF2A-to-partner and partner-to-EIF2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to arsenite ion grouped by EIF2A-low versus EIF2A-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2A→partner) and Y-score (partner→EIF2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Response to arsenite ion →	+0.143	+0.862	<.001	<.001	3	16
SKIN	Cellular response to arsenite ion →	+0.143	+0.862	<.001	<.001	3	16
LUNG_SCLC	Ribosomal large subunit export from nucleus →	+0.103	+0.477	<.001	.003	3	15
SKIN	Somatic cell DNA recombination →	+0.065	+0.624	<.001	<.001	3	12
SKIN	Somatic diversification of immune receptors via germline recombination within a single locus →	+0.065	+0.624	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	tRNA wobble cytosine modification →	+0.076	+0.724	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,616 associations by consensus.

Response to arsenite ion by EIF2A expression — SKIN

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