EIF2A

Across TCGA cell cohorts, EIF2A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EIF2A-associated genes across cancer lineages are C4orf50, TRIM77, and OR11H1. Each is linked with EIF2A in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF2A-to-partner and partner-to-EIF2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf50 grouped by EIF2A-low versus EIF2A-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF2A→partner) and Y-score (partner→EIF2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.030	+5.357	<.001	.003	3	1
BLOOD_Leukemia	OR11H1 →	+0.097	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR4K2 →	+0.042	+5.969	<.001	.001	3	1
BLOOD_Leukemia	PRORY →	+0.173	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR11G2 →	+0.392	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

C4orf50 by EIF2A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →