EIF1B

Across TCGA pan-cancer cohorts, EIF1B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated EIF1B data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EIF1B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF1B expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

UCEC, HNSC, and PDAC are the cancer types where EIF1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.321	1.000	.008	28	view →
HNSC	DFS	Median	II,III,IV	0.892	0.996	.003	20	view →
PDAC	DFS	Tertile	All	0.915	0.636	.009	18	view →
LSCC	DFS	Median	II,III,IV	1.000	0.419	.008	8	view →
CCRCC	DFS	Quartile	III,IV	0.319	0.763	.024	3	view →
LUAD	OS	Median	III,IV	0.757	0.345	.035	2	view →
GBM	OS	Tertile	All	0.942	0.764	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

EIF1B–UCEC (DFS)

Open the UCEC breakdown →