EIF1B

Across TCGA patient cohorts, EIF1B mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF1B-associated genes across cancer lineages are PEDS1-UBE2V1, IL21, and ATF4P2. Each is linked with EIF1B in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF1B-to-partner and partner-to-EIF1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEDS1-UBE2V1 grouped by EIF1B-low versus EIF1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF1B→partner) and Y-score (partner→EIF1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEDS1-UBE2V1 →	+0.033	+3.265	.007	.005	3	1
UCEC	IL21 →	+0.218	+4.611	<.001	<.001	3	1
UCEC	ATF4P2 →	+0.075	+4.014	<.001	<.001	3	1
UCEC	MIR8082 →	+0.894	+3.976	<.001	<.001	3	1
UCEC	RPL23AP4 →	+0.166	+3.302	<.001	.009	3	1
UCEC	FABP5P5 →	+0.137	+4.005	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PEDS1-UBE2V1 by EIF1B expression — UCEC

Explore this box plot interactively →