EIF1AX

Across TCGA pan-cancer cohorts, EIF1AX mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EIF1AX data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher EIF1AX mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated EIF1AX expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

CCRCC, HNSC, and LSCC are the cancer types where EIF1AX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.624	0.845	.001	18	view →
HNSC	DFS	Median	IV	0.546	0.787	.013	18	view →
LSCC	DFS	Quartile	II,III,IV	0.954	0.563	.004	15	view →
UCEC	DFS	Tertile	All	0.976	0.790	.021	10	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EIF1AX–CCRCC (DFS)

Open the CCRCC breakdown →