EIF1AX

Across TCGA patient cohorts, EIF1AX mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF1AX-associated genes across cancer lineages are EGFR_pY1068, EGFR_pY1173, and ERK2. Each is linked with EIF1AX in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF1AX-to-partner and partner-to-EIF1AX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EIF1AX-low versus EIF1AX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF1AX→partner) and Y-score (partner→EIF1AX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.203	-1.321	.015	.029	3	1
UCEC	EGFR_pY1173 →	+0.059	+1.348	.027	.018	3	1
UCEC	ERK2 →	+0.190	+1.874	.003	.002	3	1
UCEC	GSK-3_pS9 →	-0.313	-1.906	.020	.014	3	1
UCEC	JNK2 →	+0.201	+1.874	.002	.002	3	1
UCEC	MEK1 →	+0.447	+3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by EIF1AX expression — UCEC

Explore this box plot interactively →