EIF1AD

Across TCGA pan-cancer cohorts, EIF1AD mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of EIF1AD’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where EIF1AD mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types EIF1AD is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where EIF1AD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EIF1AD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	+0.632	<.001	12	view →
COAD	Female	All	−0.573	<.001	10	view →
HNSC	All	All	+0.183	<.001	10	view →
LUAD	Male	All	+0.387	<.001	9	view →
LSCC	Male	II,III,IV	+0.240	<.001	5	view →
OV	All	All	+0.772	.014	2	view →
PDAC	Female	All	−0.251	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

EIF1AD–CCRCC

Open the CCRCC breakdown →