EIF1

Across TCGA patient cohorts, EIF1 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EIF1-associated genes across cancer lineages are HSPA4, GABARAPL2, and ST7L. Each is linked with EIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EIF1-to-partner and partner-to-EIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPA4 grouped by EIF1-low versus EIF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF1→partner) and Y-score (partner→EIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPA4 →	+0.501	+3.191	.008	.009	3	1
UCEC	GABARAPL2 →	+0.563	+3.234	.004	.009	3	1
UCEC	ST7L →	+0.484	+3.234	.002	.009	3	1
UCEC	ATP6V1D →	+0.575	+3.210	.005	.009	3	1
UCEC	IL26 →	+0.178	+4.116	.004	<.001	3	1
UCEC	PEDS1-UBE2V1 →	+0.039	+3.943	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

HSPA4 by EIF1 expression — UCEC

Explore this box plot interactively →