EIF1

Across TCGA cell cohorts, EIF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,245 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EIF1-associated GO terms across cancer lineages are PERK-mediated unfolded protein response, Regulation of determination of dorsal identity, and Leading strand elongation. Each is linked with EIF1 in more than 10 cancer types. Because this analysis shows association rather than direction, both EIF1-to-partner and partner-to-EIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PERK-mediated unfolded protein response grouped by EIF1-low versus EIF1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EIF1→partner) and Y-score (partner→EIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PERK-mediated unfolded protein response →	+0.189	+0.893	<.001	<.001	3	11
BONE	Regulation of determination of dorsal identity →	+0.315	+0.753	<.001	.003	3	10
PANCREAS	Leading strand elongation →	-0.156	-0.656	.001	.004	3	10
BLOOD_Myeloma	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress →	+0.136	+0.827	.003	.001	3	9
BLOOD_Myeloma	Negative regulation of translation in response to endoplasmic reticulum stress →	+0.148	+0.728	<.001	.003	2	9
OVARY	Positive regulation of response to endoplasmic reticulum stress →	+0.087	+0.872	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,245 associations by consensus.

PERK-mediated unfolded protein response by EIF1 expression — BLOOD_Myeloma

Explore this box plot interactively →