EI24

Across TCGA patient cohorts, EI24 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EI24-associated genes across cancer lineages are A-Raf_pS299, JNK2, and p62 Lck ligand. Each is linked with EI24 in more than 1 cancer types. Because this analysis shows association rather than direction, both EI24-to-partner and partner-to-EI24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by EI24-low versus EI24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EI24→partner) and Y-score (partner→EI24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.151	-3.584	.009	.002	3	1
UCEC	JNK2 →	+0.250	+2.459	.009	.020	3	1
UCEC	p62 Lck ligand →	+0.318	+3.179	.043	.010	3	1
UCEC	Tuberin →	+0.436	+3.009	<.001	.019	3	1
UCEC	mTOR_pS2448 →	-0.146	-2.980	.042	.036	2	1
UCEC	Annexin-1 →	+0.783	+3.019	.002	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

A-Raf_pS299 by EI24 expression — UCEC

Explore this box plot interactively →