Across TCGA patient cohorts, EHMT2 mutation is significantly associated with the RNA expression of many other genes, with 3,372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EHMT2-associated genes across cancer lineages are LRRC18, XIRP1, and FAXDC2. Each is linked with EHMT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both EHMT2-to-partner and partner-to-EHMT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHMT2→partner) and Y-score (partner→EHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LRRC18 →	-0.708	-3.700	.004	.001	3	3
UCEC	XIRP1 →	+0.207	+2.635	<.001	<.001	3	3
UCEC	FAXDC2 →	-0.743	-1.893	<.001	<.001	3	3
UCEC	MSANTD3 →	+0.561	+1.903	<.001	<.001	3	3
UCEC	ACACB →	-0.409	-2.393	.001	.003	3	3
UCEC	EZR →	+0.474	+2.526	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,372 associations by consensus.

Exploration

EHMT2 survival (RNA) · tumor vs normal (RNA) · all EHMT2 data types