Across TCGA patient cohorts, EHMT2 mutation is significantly associated with the total protein of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EHMT2-associated genes across cancer lineages are HER3_pY1289, Rad50, and Rab11. Each is linked with EHMT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both EHMT2-to-partner and partner-to-EHMT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHMT2→partner) and Y-score (partner→EHMT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.062	+1.434	.029	.027	3	4
UCEC	Rad50 →	-0.166	-1.687	.037	.040	3	3
STAD	Rab11 →	-0.186	-3.000	.036	.036	3	2
STAD	Caspase-7-cleavedD198 →	+0.917	+3.000	.017	.036	3	2
COAD	GAPDH →	+0.522	+3.330	.028	.005	3	2
UCEC	MEK1 →	+0.365	+1.925	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

Exploration

EHMT2 survival (RNA) · tumor vs normal (RNA) · all EHMT2 data types