EHMT1

Across TCGA patient cohorts, EHMT1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EHMT1-associated genes across cancer lineages are PCNA, TFRC, and Cyclin-E2. Each is linked with EHMT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both EHMT1-to-partner and partner-to-EHMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by EHMT1-low versus EHMT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHMT1→partner) and Y-score (partner→EHMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PCNA →	+0.211	+3.000	.035	.034	3	3
UCEC	TFRC →	+0.444	+2.000	.001	.002	3	3
CESC	Cyclin-E2 →	+0.145	+3.169	.017	.017	1	4
UCEC	eEF2 →	+0.289	+1.428	.002	.001	3	2
UCEC	EGFR_pY1068 →	-0.201	-1.137	.002	.008	3	2
SKCM	ERK2 →	+0.221	+3.169	.043	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

PCNA by EHMT1 expression — SKCM

Explore this box plot interactively →