EHMT1

Across TCGA cell cohorts, EHMT1 mutation is significantly associated with the RNA expression of many other genes, with 1,399 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EHMT1-associated genes across cancer lineages are OR1J1, ACP4, and ABCG4. Each is linked with EHMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EHMT1-to-partner and partner-to-EHMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1J1 grouped by EHMT1-low versus EHMT1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHMT1→partner) and Y-score (partner→EHMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR1J1 →	+0.124	+3.999	<.001	.004	3	2
SOFT_TISSUE	ACP4 →	+0.039	+4.295	<.001	.002	3	2
LUNG_NSCLC_LUAD	ABCG4 →	+0.329	+3.256	.008	.009	3	2
LARGE_INTESTINE	SMCHD1 →	+0.850	+3.321	<.001	.002	3	2
LARGE_INTESTINE	TRIM35 →	+0.668	+2.064	<.001	.004	3	2
LARGE_INTESTINE	INTS10 →	+0.694	+4.130	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,399 associations by consensus.

OR1J1 by EHMT1 expression — SOFT_TISSUE

Explore this box plot interactively →