EHD4

Across TCGA patient cohorts, EHD4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EHD4-associated genes across cancer lineages are Rad50, Raptor, and ATM. Each is linked with EHD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EHD4-to-partner and partner-to-EHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by EHD4-low versus EHD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHD4→partner) and Y-score (partner→EHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.209	-2.308	.021	.033	3	2
UCEC	Raptor →	-0.129	-1.765	.024	.014	3	2
UCEC	ATM →	-0.726	-3.321	<.001	<.001	3	2
UCEC	eEF2 →	+0.274	+1.874	.041	.049	3	1
UCEC	EGFR_pY1068 →	-0.223	-1.765	.017	.014	3	1
UCEC	ERK2 →	+0.207	+2.169	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Rad50 by EHD4 expression — UCEC

Explore this box plot interactively →