EHD4

Across TCGA cell cohorts, EHD4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EHD4-associated genes across cancer lineages are HHLA1, CNGA2, and PRR23A. Each is linked with EHD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EHD4-to-partner and partner-to-EHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HHLA1 grouped by EHD4-low versus EHD4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHD4→partner) and Y-score (partner→EHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	CNGA2 →	+0.074	+4.539	<.001	.007	3	1
BLOOD_Leukemia	PRR23A →	+0.028	+5.269	.006	<.001	3	1
BLOOD_Lymphoma	FSHB →	+0.012	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	OR52B2 →	+0.021	+4.714	.006	.002	3	1
SKIN	DEFB125 →	+0.044	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

HHLA1 by EHD4 expression — BLOOD_Leukemia

Explore this box plot interactively →