EHD4

Across TCGA cell cohorts, EHD4 mutation is significantly associated with the mutation status of many other genes, with 2,263 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EHD4-associated genes across cancer lineages are UBE4B, ZNF365, and SNX27. Each is linked with EHD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both EHD4-to-partner and partner-to-EHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE4B grouped by EHD4-low versus EHD4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHD4→partner) and Y-score (partner→EHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	UBE4B →	+4.392	+4.954	.008	.008	1	4
BLOOD_Leukemia	ZNF365 →	+3.145	+3.932	.004	.004	1	4
BLOOD_Lymphoma	SNX27 →	+5.584	+5.014	.003	.003	1	4
UPPER_AERODIGESTIVE_TRACT	SMG6 →	+4.392	+4.954	.008	.008	1	4
LARGE_INTESTINE	CHRM3 →	+2.729	+3.643	<.001	<.001	1	4
BLOOD_Lymphoma	RSF1 →	+5.584	+5.014	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,263 associations by consensus.

UBE4B by EHD4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →