EHD3

Across TCGA patient cohorts, EHD3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EHD3-associated genes across cancer lineages are Di-Ras3, MEK1, and Shc_pY317. Each is linked with EHD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both EHD3-to-partner and partner-to-EHD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by EHD3-low versus EHD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHD3→partner) and Y-score (partner→EHD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.150	-4.156	<.001	<.001	3	3
UCEC	MEK1 →	+0.418	+2.099	<.001	<.001	3	3
UCEC	Shc_pY317 →	-0.152	-1.857	<.001	<.001	3	3
UCEC	ATM →	-0.647	-2.369	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.407	+3.321	<.001	<.001	3	3
SKCM	SCD →	-0.197	-3.169	.003	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Di-Ras3 by EHD3 expression — UCEC

Explore this box plot interactively →