EHD1

Across TCGA patient cohorts, EHD1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EHD1-associated genes across cancer lineages are Notch1, A-Raf_pS299, and p62 Lck ligand. Each is linked with EHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EHD1-to-partner and partner-to-EHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by EHD1-low versus EHD1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHD1→partner) and Y-score (partner→EHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	Notch1 →	+0.397	+2.814	<.001	.037	3	2
UCEC	A-Raf_pS299 →	-0.138	-2.459	.004	.019	3	2
UCEC	p62 Lck ligand →	+0.375	+2.009	.004	.017	3	2
SKCM	NF-kB-p65_pS536 →	+0.497	+3.000	.026	.036	3	1
UCEC	eIF4E →	+0.196	+1.906	.021	.016	3	1
UCEC	ERK2 →	+0.249	+1.906	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Notch1 by EHD1 expression — BRCA

Explore this box plot interactively →