EHBP1L1

Across TCGA cell cohorts, EHBP1L1 mutation is significantly associated with the RNA expression of many other genes, with 557 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EHBP1L1-associated genes across cancer lineages are SPINK8, PARD6A, and CTSS. Each is linked with EHBP1L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EHBP1L1-to-partner and partner-to-EHBP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK8 grouped by EHBP1L1-low versus EHBP1L1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EHBP1L1→partner) and Y-score (partner→EHBP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINK8 →	+0.438	+5.228	<.001	.005	3	2
BLOOD_Leukemia	PARD6A →	+0.955	+3.215	<.001	.005	3	2
BLOOD_Leukemia	CTSS →	-1.954	-3.292	<.001	.007	3	2
BLOOD_Leukemia	FOXS1 →	+0.049	+3.399	<.001	<.001	3	2
LARGE_INTESTINE	GPR63 →	+1.185	+3.212	<.001	.006	3	2
LARGE_INTESTINE	TXNDC15 →	+0.639	+3.212	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 557 associations by consensus.

SPINK8 by EHBP1L1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →