EGR4

Across TCGA patient cohorts, EGR4 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGR4-associated genes across cancer lineages are eEF2, EGFR_pY1173, and Gab2. Each is linked with EGR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGR4-to-partner and partner-to-EGR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by EGR4-low versus EGR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR4→partner) and Y-score (partner→EGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.429	+3.321	.002	.009	3	2
UCEC	EGFR_pY1173 →	+0.065	+1.933	.042	.009	3	2
UCEC	Gab2 →	+0.316	+2.321	.028	.034	3	2
UCEC	Ku80 →	+0.223	+1.920	.019	.009	3	2
UCEC	p21 →	+0.153	+2.820	.048	.035	3	2
UCEC	Cyclin-E2 →	+0.224	+3.594	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eEF2 by EGR4 expression — UCEC

Explore this box plot interactively →