EGR4

Across TCGA cell cohorts, EGR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 803 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EGR4-associated GO terms across cancer lineages are Response to interleukin-8, Cellular response to interleukin-8, and Mitotic centrosome separation. Each is linked with EGR4 in more than 4 cancer types. Because this analysis shows association rather than direction, both EGR4-to-partner and partner-to-EGR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-8 grouped by EGR4-low versus EGR4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR4→partner) and Y-score (partner→EGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to interleukin-8 →	+0.926	+0.266	.002	.006	3	5
LUNG_SCLC	Cellular response to interleukin-8 →	+0.926	+0.266	.002	.006	3	5
UPPER_AERODIGESTIVE_TRACT	Mitotic centrosome separation →	+0.113	+0.092	.003	.003	3	4
BLOOD_Leukemia	Cell proliferation involved in kidney development →	+0.144	+0.203	.005	.002	3	4
BLOOD_Lymphoma	Protein localization to condensed chromosome →	-0.065	-0.251	.001	.003	3	4
LUNG_NSCLC_LUSC	Cholesterol efflux →	+0.095	+0.117	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 803 associations by consensus.

Response to interleukin-8 by EGR4 expression — LUNG_SCLC

Explore this box plot interactively →