EGR4

Across TCGA cell cohorts, EGR4 mutation is significantly associated with the RNA expression of many other genes, with 98 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGR4-associated genes across cancer lineages are CNMD, MRGPRG, and OR56A4. Each is linked with EGR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGR4-to-partner and partner-to-EGR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNMD grouped by EGR4-low versus EGR4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR4→partner) and Y-score (partner→EGR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CNMD →	+0.284	+3.807	.001	.007	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.022	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR56A4 →	+0.174	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	LILRA5 →	+0.036	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	BTNL2 →	+0.073	+3.760	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR2H1 →	+0.171	+3.866	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

CNMD by EGR4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →