EGR3

Across TCGA patient cohorts, EGR3 mutation is significantly associated with the RNA expression of many other genes, with 4,283 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGR3-associated genes across cancer lineages are CCL4, CENPU, and SLC25A4. Each is linked with EGR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGR3-to-partner and partner-to-EGR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL4 grouped by EGR3-low versus EGR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR3→partner) and Y-score (partner→EGR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL4 →	+1.052	+2.960	<.001	<.001	3	2
UCEC	CENPU →	+0.744	+2.970	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.641	+3.010	<.001	<.001	3	2
UCEC	ATP5F1A →	+0.463	+3.882	.001	<.001	3	2
UCEC	C18orf25 →	+0.480	+2.949	<.001	<.001	3	2
UCEC	ABHD3 →	+0.836	+2.949	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,283 associations by consensus.

CCL4 by EGR3 expression — UCEC

Explore this box plot interactively →