EGR3

Across TCGA cell cohorts, EGR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,673 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible EGR3-associated GO terms across cancer lineages are Response to interleukin-8, Cellular response to interleukin-8, and Circadian temperature homeostasis. Each is linked with EGR3 in more than 13 cancer types. Because this analysis shows association rather than direction, both EGR3-to-partner and partner-to-EGR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-8 grouped by EGR3-low versus EGR3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR3→partner) and Y-score (partner→EGR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to interleukin-8 →	+1.514	+0.891	<.001	.002	3	14
LUNG_SCLC	Cellular response to interleukin-8 →	+1.514	+0.891	<.001	.002	3	14
BLOOD_Leukemia	Circadian temperature homeostasis →	+0.874	+0.788	<.001	<.001	3	13
BLOOD_Leukemia	Cellular response to heparin →	+1.385	+1.066	<.001	<.001	3	11
BREAST	Negative regulation of transcription by RNA polymerase III →	+0.147	+1.729	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Estrous cycle →	+0.171	+0.583	<.001	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,673 associations by consensus.

Response to interleukin-8 by EGR3 expression — LUNG_SCLC

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