EGR2

Across TCGA cell cohorts, EGR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,866 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EGR2-associated GO terms across cancer lineages are Response to interleukin-8, Cellular response to interleukin-8, and Circadian temperature homeostasis. Each is linked with EGR2 in more than 14 cancer types. Because this analysis shows association rather than direction, both EGR2-to-partner and partner-to-EGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-8 grouped by EGR2-low versus EGR2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR2→partner) and Y-score (partner→EGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Response to interleukin-8 →	+1.138	+1.680	<.001	<.001	3	15
BLOOD_Lymphoma	Cellular response to interleukin-8 →	+1.138	+1.680	<.001	<.001	3	15
BLOOD_Leukemia	Circadian temperature homeostasis →	+0.777	+0.652	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Regulation of Schwann cell differentiation →	-0.160	-0.596	<.001	<.001	3	11
BLOOD_Leukemia	Cellular response to heparin →	+1.152	+0.964	<.001	<.001	3	9
OESOPHAGUS	Response to corticotropin-releasing hormone →	+1.543	+1.955	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,866 associations by consensus.

Response to interleukin-8 by EGR2 expression — BLOOD_Lymphoma

Explore this box plot interactively →