EGR2

Across TCGA cell cohorts, EGR2 mutation is significantly associated with the RNA expression of many other genes, with 649 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGR2-associated genes across cancer lineages are GGA1, GCAT, and CBY1. Each is linked with EGR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGR2-to-partner and partner-to-EGR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGA1 grouped by EGR2-low versus EGR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR2→partner) and Y-score (partner→EGR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GGA1 →	+0.522	+2.043	.007	.008	3	1
LARGE_INTESTINE	GCAT →	+1.322	+3.584	<.001	<.001	3	1
LARGE_INTESTINE	CBY1 →	+0.472	+2.129	.007	.007	3	1
LARGE_INTESTINE	MCAT →	+0.631	+3.321	<.001	.003	3	1
LARGE_INTESTINE	MCM5 →	+0.656	+3.169	.003	.006	3	1
LARGE_INTESTINE	SGSM3 →	+0.694	+2.743	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 649 associations by consensus.

GGA1 by EGR2 expression — LARGE_INTESTINE

Explore this box plot interactively →