EGR1

Across TCGA patient cohorts, EGR1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGR1-associated genes across cancer lineages are PAI-1, Rad50, and Caspase-7-cleavedD198. Each is linked with EGR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both EGR1-to-partner and partner-to-EGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by EGR1-low versus EGR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR1→partner) and Y-score (partner→EGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.232	+1.584	.047	.017	3	3
UCEC	Rad50 →	-0.192	-1.247	.020	.045	3	2
UCEC	Caspase-7-cleavedD198 →	+0.774	+2.341	<.001	.003	3	2
UCEC	GAPDH →	+0.368	+1.584	.044	.034	3	1
UCEC	JNK2 →	+0.244	+1.594	<.001	.021	3	1
UCEC	Ku80 →	+0.252	+1.527	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

PAI-1 by EGR1 expression — UCEC

Explore this box plot interactively →