EGR1

Across TCGA cell cohorts, EGR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,187 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EGR1-associated GO terms across cancer lineages are Response to interleukin-8, Cellular response to interleukin-8, and Circadian temperature homeostasis. Each is linked with EGR1 in more than 19 cancer types. Because this analysis shows association rather than direction, both EGR1-to-partner and partner-to-EGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to interleukin-8 grouped by EGR1-low versus EGR1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR1→partner) and Y-score (partner→EGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to interleukin-8 →	+2.075	+3.359	<.001	<.001	3	20
LUNG_SCLC	Cellular response to interleukin-8 →	+2.075	+3.359	<.001	<.001	3	20
LUNG_SCLC	Circadian temperature homeostasis →	+1.273	+2.862	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Cellular response to parathyroid hormone stimulus →	+1.562	+2.862	<.001	<.001	3	19
BLOOD_Leukemia	Cellular response to heparin →	+1.661	+3.323	<.001	<.001	3	19
BLOOD_Leukemia	Response to heparin →	+1.805	+3.139	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,187 associations by consensus.

Response to interleukin-8 by EGR1 expression — LUNG_SCLC

Explore this box plot interactively →