EGR1

Across TCGA cell cohorts, EGR1 mutation is significantly associated with the RNA expression of many other genes, with 513 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGR1-associated genes across cancer lineages are CDCP2, DEFA3, and NPPB. Each is linked with EGR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGR1-to-partner and partner-to-EGR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCP2 grouped by EGR1-low versus EGR1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGR1→partner) and Y-score (partner→EGR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDCP2 →	+0.023	+4.095	<.001	.009	3	1
SKIN	DEFA3 →	+0.105	+4.415	<.001	.007	3	1
BLOOD_Leukemia	NPPB →	+0.128	+3.662	<.001	.003	3	1
BLOOD_Leukemia	NUDT10 →	+1.253	+3.754	<.001	.002	3	1
BLOOD_Leukemia	SH3GL3 →	+1.253	+3.518	.005	.008	3	1
BLOOD_Leukemia	ADAMTS18 →	+0.610	+3.605	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 513 associations by consensus.

CDCP2 by EGR1 expression — SKIN

Explore this box plot interactively →