EGOT

Across TCGA pan-cancer cohorts, EGOT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated EGOT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher EGOT RNA is associated with better overall survival. In most high-consensus cancer types, elevated EGOT expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BRCA, and LGG are the cancer types where EGOT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.704	0.552	<.001	118	view →
BRCA	DFS	Tertile	All	0.936	0.866	<.001	102	view →
LGG	OS	Median	All	0.849	0.927	<.001	37	view →
HNSC	DFS	Median	All	0.744	0.645	.002	36	view →
PAAD	OS	Quartile	All	0.279	0.574	.001	29	view →
ACC	OS	Median	IV	0.799	0.287	.006	27	view →
LIHC	DFS	Median	II,III,IV	0.203	0.478	.001	25	view →
BLCA	OS	Tertile	IV	0.330	0.693	.010	24	view →
SKCM	OS	Median	III,IV	0.498	0.316	.003	22	view →
OV	DFS	Median	III,IV	0.336	0.408	.018	16	view →
THCA	DFS	Median	All	0.915	0.968	.016	14	view →
MESO	OS	Quartile	IV	0.324	0.770	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

EGOT–KIRC (OS)

Open the KIRC breakdown →