EGLN3

Across TCGA cell cohorts, EGLN3 mutation is significantly associated with the mutation status of many other genes, with 167 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible EGLN3-associated genes across cancer lineages are TBX3, PANX3, and HSPA4L. Each is linked with EGLN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGLN3-to-partner and partner-to-EGLN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX3 grouped by EGLN3-low versus EGLN3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGLN3→partner) and Y-score (partner→EGLN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TBX3 →	+6.014	+6.014	.001	.001	1	2
BLOOD_Lymphoma	PANX3 →	+4.014	+4.969	.008	.008	1	2
BLOOD_Lymphoma	HSPA4L →	+4.014	+4.969	.008	.008	1	2
BLOOD_Lymphoma	SPRED1 →	+5.014	+5.584	.003	.003	1	2
BLOOD_Lymphoma	LONRF3 →	+5.014	+5.584	.003	.003	1	2
BLOOD_Lymphoma	USP14 →	+4.429	+5.247	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

TBX3 by EGLN3 expression — BLOOD_Lymphoma

Explore this box plot interactively →