EGLN2

Across TCGA cell cohorts, EGLN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,729 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible EGLN2-associated GO terms across cancer lineages are Negative regulation of intracellular estrogen receptor signaling pathway, Peptidyl-proline hydroxylation, and Peptidyl-proline modification. Each is linked with EGLN2 in more than 13 cancer types. Because this analysis shows association rather than direction, both EGLN2-to-partner and partner-to-EGLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of intracellular estrogen receptor signaling pathway grouped by EGLN2-low versus EGLN2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGLN2→partner) and Y-score (partner→EGLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of intracellular estrogen receptor signaling pathway →	+0.123	+1.031	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Peptidyl-proline hydroxylation →	+0.225	+0.831	.002	.006	1	14
BLOOD_Myeloma	Peptidyl-proline modification →	+0.136	+1.010	<.001	.003	3	11
OVARY	Regulation of TORC2 signaling →	+0.121	+0.583	<.001	.001	3	11
SKIN	Positive regulation of TORC2 signaling →	+0.093	+0.465	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.092	+0.858	<.001	<.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,729 associations by consensus.

Negative regulation of intracellular estrogen receptor signaling pathway by EGLN2 expression — BREAST

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