EGLN2

Across TCGA cell cohorts, EGLN2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EGLN2-associated genes across cancer lineages are IRX4, BTBD16, and SDR9C7. Each is linked with EGLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGLN2-to-partner and partner-to-EGLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRX4 grouped by EGLN2-low versus EGLN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGLN2→partner) and Y-score (partner→EGLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IRX4 →	+0.144	+3.847	<.001	.004	3	1
BLOOD_Leukemia	BTBD16 →	+0.065	+3.696	.001	.006	3	1
BLOOD_Leukemia	SDR9C7 →	+0.064	+3.720	<.001	.005	3	1
BLOOD_Leukemia	MAGEE2 →	+0.216	+4.177	<.001	.001	3	1
BLOOD_Leukemia	OR6K3 →	+0.083	+3.691	<.001	.002	3	1
BLOOD_Leukemia	TXNDC8 →	+0.008	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

IRX4 by EGLN2 expression — BLOOD_Leukemia

Explore this box plot interactively →