EGLN1

Across TCGA cell cohorts, EGLN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,742 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EGLN1-associated GO terms across cancer lineages are Regulation protein catabolic process at synapse, Regulation of modification of synaptic structure, and Regulation of modification of postsynaptic structure. Each is linked with EGLN1 in more than 16 cancer types. Because this analysis shows association rather than direction, both EGLN1-to-partner and partner-to-EGLN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation protein catabolic process at synapse grouped by EGLN1-low versus EGLN1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGLN1→partner) and Y-score (partner→EGLN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation protein catabolic process at synapse →	+0.249	+0.826	<.001	<.001	3	17
STOMACH	Regulation of modification of synaptic structure →	+0.112	+0.961	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Regulation of modification of postsynaptic structure →	+0.167	+1.123	<.001	<.001	3	15
BONE	Intracellular oxygen homeostasis →	+0.212	+0.955	<.001	.001	3	13
BREAST	Response to nitric oxide →	+0.135	+1.124	<.001	<.001	3	12
CNS	Negative regulation of Rho protein signal transduction →	+0.173	+0.837	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,742 associations by consensus.

Regulation protein catabolic process at synapse by EGLN1 expression — BONE

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