EGFR

Across TCGA patient cohorts, EGFR RNA expression is significantly associated with the protein abundance of many other proteins, with 16,539 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible EGFR-associated proteins across cancer lineages are EGFR_S991, EGFR_T693, and PHLDA3. Each is linked with EGFR in more than 6 cancer types. Because this analysis shows association rather than direction, both EGFR-to-partner and partner-to-EGFR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EGFR versus EGFR_S991 in GBM, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFR→partner) and Y-score (partner→EGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EGFR_S991 →	+0.755	+2.908	<.001	<.001	3	7
PDAC	EGFR_T693 →	+1.201	+0.767	<.001	<.001	3	7
GBM	PHLDA3 →	+0.705	+2.365	<.001	<.001	3	6
GBM	EGFR_S1064 →	+1.812	+3.540	<.001	<.001	3	6
GBM	LANCL2 →	+0.967	+1.885	<.001	<.001	3	6
HNSC	PLCG2 →	-0.471	-1.533	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,539 associations by consensus.

EGFR vs EGFR_S991 — GBM

Explore this scatter interactively →