EGFR

Across TCGA patient cohorts, EGFR protein abundance is significantly associated with the RNA expression of many other genes, with 14,624 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible EGFR-associated genes across cancer lineages are EGFR-AS1, SEC61G, and ATP2A3. Each is linked with EGFR in more than 8 cancer types. Because this analysis shows association rather than direction, both EGFR-to-partner and partner-to-EGFR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EGFR versus EGFR-AS1 in GBM, with a Pearson correlation of 0.88.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFR→partner) and Y-score (partner→EGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EGFR-AS1 →	+4.012	+2.116	<.001	<.001	3	9
GBM	SEC61G →	+2.457	+1.423	<.001	<.001	3	8
LSCC	ATP2A3 →	-1.085	-0.734	<.001	<.001	3	7
BRCA	CAV2 →	+0.976	+0.640	<.001	<.001	3	6
OV	PPP1R13L →	+1.108	+0.359	.001	.002	3	6
LSCC	ITGB8 →	+1.248	+0.701	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,624 associations by consensus.

EGFR vs EGFR-AS1 — GBM

Explore this scatter interactively →