EGFR

Across TCGA patient cohorts, EGFR mutation is significantly associated with the RNA expression of many other genes, with 12,205 significant associations in total. LGG shows the largest number of these associations.

The most reproducible EGFR-associated genes across cancer lineages are TIMM44, CENPM, and PKMYT1. Each is linked with EGFR in more than 7 cancer types. Because this analysis shows association rather than direction, both EGFR-to-partner and partner-to-EGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM44 grouped by EGFR-low versus EGFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFR→partner) and Y-score (partner→EGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMM44 →	+0.357	+1.816	<.001	<.001	3	8
LGG	CENPM →	+0.993	+3.154	<.001	<.001	3	6
LGG	PKMYT1 →	+0.923	+2.557	<.001	<.001	3	6
LUAD	ENO1 →	+0.489	+2.127	<.001	<.001	3	6
LGG	ZIC2 →	+1.118	+3.655	<.001	<.001	3	5
LUAD	WDR83OS →	+0.236	+2.222	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,205 associations by consensus.

TIMM44 by EGFR expression — UCEC

Explore this box plot interactively →