EGFR

Across TCGA cell cohorts, EGFR RNA expression is significantly associated with the go_rna of many other GO terms, with 5,777 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EGFR-associated GO terms across cancer lineages are Regulation of fibroblast proliferation, Regulation of plasma membrane repair, and Positive regulation of canonical NF-kappaB signal transduction. Each is linked with EGFR in more than 14 cancer types. Because this analysis shows association rather than direction, both EGFR-to-partner and partner-to-EGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fibroblast proliferation grouped by EGFR-low versus EGFR-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFR→partner) and Y-score (partner→EGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of fibroblast proliferation →	+0.129	+3.384	.001	.001	3	15
BONE	Regulation of plasma membrane repair →	+0.423	+3.191	<.001	<.001	3	15
SOFT_TISSUE	Positive regulation of canonical NF-kappaB signal transduction →	+0.058	+2.600	<.001	<.001	3	14
LUNG_SCLC	Positive regulation of plasma membrane repair →	+0.502	+2.261	.004	<.001	3	14
SOFT_TISSUE	Maintenance of protein location →	+0.143	+3.027	<.001	<.001	3	13
LUNG_SCLC	Cellular response to abiotic stimulus →	+0.054	+2.679	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,777 associations by consensus.

Regulation of fibroblast proliferation by EGFR expression — LUNG_NSCLC_LUSC

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