EGFLAM

Across TCGA pan-cancer cohorts, EGFLAM Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated EGFLAM data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher EGFLAM Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated EGFLAM expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

THYM, UCS, and BRCA are the cancer types where EGFLAM Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCS	OS	Median	All	0.217	0.695	.001	36	view →
BRCA	OS	Median	All	0.759	0.963	<.001	28	view →
PAAD	DFS	Median	All	0.150	0.485	.016	21	view →
UCEC	DFS	Median	All	0.766	0.631	.013	16	view →
OV	OS	Median	IV	0.028	0.759	.002	12	view →
COAD	OS	Median	IV	0.056	0.659	<.001	12	view →
LUAD	DFS	Median	All	0.942	0.653	.009	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
STAD	DFS	Median	All	0.240	0.713	.004	3	view →
SKCM	OS	Median	All	0.228	0.359	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

EGFLAM–THYM (OS)

Open the THYM breakdown →