EGFL8

Across TCGA patient cohorts, EGFL8 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,132 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EGFL8-associated proteins across cancer lineages are PARP4, SMC1A, and SPIN1. Each is linked with EGFL8 in more than 4 cancer types. Because this analysis shows association rather than direction, both EGFL8-to-partner and partner-to-EGFL8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EGFL8 versus PARP4 in GBM, with a Pearson correlation of -0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFL8→partner) and Y-score (partner→EGFL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PARP4 →	-0.457	-0.282	<.001	<.001	3	5
LSCC	SMC1A →	+0.297	+0.249	<.001	.004	3	4
LSCC	SPIN1 →	+0.378	+0.383	.002	<.001	3	4
COAD	NONO →	+0.156	+0.464	<.001	<.001	3	4
LSCC	PNN →	+0.367	+0.402	<.001	<.001	3	4
LSCC	POLR2B →	+0.182	+0.264	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,132 associations by consensus.

EGFL8 vs PARP4 — GBM

Explore this scatter interactively →