EGFL8

Across TCGA patient cohorts, EGFL8 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EGFL8-associated genes across cancer lineages are Tuberin, eIF4E, and p62 Lck ligand. Each is linked with EGFL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both EGFL8-to-partner and partner-to-EGFL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by EGFL8-low versus EGFL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFL8→partner) and Y-score (partner→EGFL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.368	+3.321	.009	.010	3	2
UCEC	eIF4E →	+0.250	+3.321	.023	.010	3	1
UCEC	p62 Lck ligand →	+0.597	+3.321	<.001	.010	3	1
UCEC	STAT3_pY705 →	-0.440	-3.321	.001	.010	3	1
UCEC	Caspase-8 →	-0.299	-2.973	.023	.035	3	1
UCEC	4E-BP1 →	+0.525	+3.029	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Tuberin by EGFL8 expression — UCEC

Explore this box plot interactively →