EGFL8

Across TCGA cell cohorts, EGFL8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,827 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EGFL8-associated GO terms across cancer lineages are Chiasma assembly, mRNA splice site recognition, and Spliceosomal complex assembly. Each is linked with EGFL8 in more than 12 cancer types. Because this analysis shows association rather than direction, both EGFL8-to-partner and partner-to-EGFL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chiasma assembly grouped by EGFL8-low versus EGFL8-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EGFL8→partner) and Y-score (partner→EGFL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Chiasma assembly →	+0.324	+1.198	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	mRNA splice site recognition →	+0.123	+1.067	<.001	<.001	3	12
OESOPHAGUS	Spliceosomal complex assembly →	+0.087	+0.815	.009	.004	3	11
SOFT_TISSUE	DNA topological change →	+0.116	+1.013	.006	.001	2	11
OVARY	Intraciliary transport →	+0.055	+0.660	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.082	+1.464	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,827 associations by consensus.

Chiasma assembly by EGFL8 expression — KIDNEY

Explore this box plot interactively →