EGFL7

Across TCGA pan-cancer cohorts, EGFL7 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of EGFL7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EGFL7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types EGFL7 is over-expressed in tumor, although a few such as COAD and OV show the opposite, repressed pattern.

COAD, PDAC, and LUAD are the cancer types where EGFL7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EGFL7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.746	<.001	8	view →
PDAC	All	All	+1.056	.012	3	view →
LUAD	Male	All	+0.653	<.001	3	view →
OV	All	All	−1.443	<.001	2	view →
CCRCC	Male	All	+0.438	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

EGFL7–COAD

Open the COAD breakdown →