EGF

Across TCGA pan-cancer cohorts, EGF Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated EGF data layer compared with 23 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher EGF Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated EGF expression acts as an unfavorable survival marker, although some lineages such as UCEC and LIHC show a favorable association.

SCLC, LUSC, and UCEC are the cancer types where EGF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.186	0.597	<.001	24	view →
LUSC	OS	Median	II,III,IV	0.241	0.639	<.001	23	view →
UCEC	DFS	Median	All	0.825	0.627	.009	18	view →
KIRC	OS	Median	All	0.167	0.655	.038	12	view →
SARC	OS	Median	All	0.178	0.730	.012	9	view →
CESC	OS	Median	All	0.092	0.587	.010	6	view →
PRAD	DFS	Median	All	0.664	0.936	.002	6	view →
LUAD	OS	Median	III,IV	0.255	0.527	.041	3	view →
LIHC	DFS	Median	II,III,IV	1.000	0.200	.024	3	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →
OV	DFS	Median	III,IV	0.546	0.149	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

EGF–SCLC (DFS)

Open the SCLC breakdown →