EFTUD2

Across TCGA patient cohorts, EFTUD2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFTUD2-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and MSH2. Each is linked with EFTUD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EFTUD2-to-partner and partner-to-EFTUD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by EFTUD2-low versus EFTUD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFTUD2→partner) and Y-score (partner→EFTUD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+1.893	.010	<.001	3	2
UCEC	A-Raf_pS299 →	-0.115	-1.678	.001	.019	3	2
UCEC	MSH2 →	-0.267	-2.143	<.001	.002	3	2
UCEC	MSH6 →	-0.303	-1.807	.003	.024	3	2
SKCM	PI3K-p85 →	+0.274	+3.012	.009	.018	3	2
UCEC	ATM →	-0.280	-1.794	.047	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eIF4E by EFTUD2 expression — UCEC

Explore this box plot interactively →